Breadcrumbs

University of Waikato researchers win funds to help fight superbugs

31 May 2021

Petrie dish

University of Waikato scientists have today received a boost in the battle against antimicrobial-resistant germs. Dr Adele Williamson and Dr William Kelton, both in collaboration with Dr Joanna Hicks, have been awarded a total of $300,000 over two years by the Health Research Council to find new ways to fight bacteria which are immune to existing medicines.

Antimicrobial resistance is one of the greatest threats to human health today. When disease-causing bacteria and viruses are exposed to medicines over time, they can mutate to protect themselves. These superbugs then become very difficult to treat, leading to severe illness and even death. It is estimated that deaths related to antimicrobial resistance will equal those caused by cancer by 2050.

Superbugs also have big economic implications. Recent modeling by the World Bank showed resistant pathogens could cause as much damage to the global economy as the 2008 financial crisis, impacting international trade and agriculture, reducing the workforce, and increasing healthcare expenditure.

An example superbug is the sexually transmitted infection gonorrhoea. Once easily treatable, gonorrhoea is now a growing health problem here in Aotearoa and around the globe due to its high number of antibiotic-resistant strains. Dr Williamson and Dr Kelton will lead two separate studies focusing on this pathogen, looking for weaknesses which may prove the key to treating it in future.

Dr Williamson will study the way gonorrhoea can repair DNA from its environment using a DNA-joining enzyme. She believes the gonorrhoea may incorporate the repaired DNA into its own genetic code to protect itself against antibiotics. If proven, this process could explain why gonorrhoea and other bacteria with this protein such as Campylobacter and Haemophilus influenzae are so good at developing antibiotic resistance.

“Understanding the mechanisms that drive antimicrobial resistance is essential for us to keep enjoying the significant benefits of antibiotic drugs in modern society,” says Dr Williamson.

“This research could lead to treatments that prevent bacteria from obtaining antimicrobial resistance and also from repairing their own DNA, making them more susceptible to existing antibiotics.”

Dr Kelton will investigate the potential for a treatment which allows antibodies to label gonorrhoea while it is hidden inside a person’s cells. This would trigger destruction of the bacteria by specialised elements of the immune system that are normally reserved for attacking viruses.

“The new knowledge gained by undertaking this research will inform efforts to treat other intracellular pathogens for which antibiotic resistance is also rising, like chlamydia and tuberculosis,” says Dr Kelton.


This research aligns with the following United Nations Sustainable Development Goals:

Good Health and Well-being

Latest stories

Related stories

Research leader and Antarctica expert to join Waikato as Deputy Vice-Chancellor Research

The University of Waikato has announced the appointment of Professor Gary Wilson to the role…

University of Waikato researchers receive record-level Marsden funding to explore bold ideas for the future

The University of Waikato is celebrating its most successful Marsden funding round yet.

Dr Rebecca Lawton Rutherford Discovery Fellow

Prestigious Rutherford Discovery Fellowship awarded to Dr Rebecca Lawton for marine kelp research

Dr Rebecca Lawton, Senior Lecturer in Marine Science and Aquaculture at the University of Waikato…

Dr Jason Mika

Significant funding boost for University of Waikato research

The University of Waikato has achieved significant results in the latest funding round from the…

Dr Haki Tuaupiki and Associate Professor Maui Hudson

Waikato researchers tapped for US$30m Centre for braiding Indigenous knowledge and science

Two University of Waikato researchers have been shoulder-tapped as investigators within the newly launched NSF…

Jo Lane

Pharmacy to add to Waikato’s health offering

The University of Waikato intends to accept its first students in a new graduate-entry Master…

Te Huataki Waiora School of Health team Dr Ryan Paul, Dr Ross Lawrenson and Dr Rawiri Keenan

Waikato bolsters health leadership team

The University of Waikato has announced three key appointments to Te Huataki Waiora School of…

IDI Lab sign

Newly refurbished Waikato IDI Lab a catalyst for fostering academic-industry collaboration

The University of Waikato re-opened its newly refurbished Integrated Data Infrastructure (IDI) Lab; a catalyst…

3MT group photo 2023

Captive kiwi management researcher takes out tight competition

Te Aka Mātuatua School of Science animal behaviour researcher Rebecca Connor won the University's 3…

Professor Chris Battershill

Renowned scientist honoured for dedication to marine conservation

World-renowned marine scientist Professor Chris Battershill has been honoured for his significant contributions to marine…

Neil Quigley and Kelvyn Eglinton

University of Waikato Medical School funding backed by Momentum Waikato

Funding for a Graduate School of Medicine at the University of Waikato will be supported…

Professor Holly Thorpe

Reimagining fields of play to grow the future of women in sport through world-class research

Waikato hosts global symposium to tackle issues from building gender-inclusive sporting environments to menstrual health…